Title: San Domino Vacation Packages 2026 | Expedia.com [San Domino Travel Guide](https://expedia.com/San-Domino.dx6125738)[Hotels in San Domino](https://expedia.com/San-Domino-Hotels.d6125738.Travel-Guide-Hotels)[Vacation Rentals in San Domino](https://expedia.com/San-Domino-Vacation-Rentals.d6125738.Travel-Guide-VacationRentals)[Flights to San Domino](https://expedia.com/Cheap-Flights-To-San-Domino.d6125738.Travel-Guide-Flights)[Car Rentals in San Domino](https://expedia.com/Car-Rentals-In-San-Domino.d6125738.Car-Rental-Guide) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # San Domino Vacations ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Discover the most popular places to visit in San Domino #### San Domino Lighthouse Learn about the local history of Tremiti Islands when you spend time at San Domino Lighthouse. Wander the beaches and waterfront while you're in the area. [](https://expedia.com/San-Domino-Lighthouse-Tremiti-Islands.d6237363.Vacation-Attraction) #### Cala delle Arene Beach Why not spend a carefree afternoon at Cala delle Arene Beach during your travels in Tremiti Islands? Wander the waterfront and parks while you're in the area. [](https://expedia.com/Cala-Delle-Arene-Beach-Tremiti-Islands.d6237350.Vacation-Attraction) #### Cala Matano If a restful vacation is part of your travel plans, Cala Matano might be the perfect place to seek out during your trip to Tremiti Islands. Wander the waterfront and parks while you're in the area. [](https://expedia.com/Cala-Matano-Tremiti-Islands.d553248634028973171.Vacation-Attraction) ## San Domino Hotel Deals ![Hotel Kyrie Isole Tremiti](https://images.trvl-media.com/lodging/5000000/4980000/4973700/4973625/bfd02c9c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Kyrie Isole Tremiti Loc. San Domino, Via dei Cameroni Tremiti Islands FG 8/10 Very Good! (131 reviews) The hotel is in a very good location, walking distance (10-15mins) from the main square with shops, restaurants and a grocery shop. The hotel is in a beautiful scenery, up on the top of the island, with complimentary (free for guests of the hotel) frequent and very convenient shuttle transport from ... Reviewed on Jul 13, 2024 [Get rates](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=4973625&PinnedHotelID=4973625&HadPinnedHotel=true®ionId=6125738) [](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=4973625&PinnedHotelID=4973625&HadPinnedHotel=true®ionId=6125738) ![Eden](https://images.trvl-media.com/lodging/3000000/2950000/2942300/2942214/5a1faf1a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Eden Via Garibaldi 1 - Isolotto Di San Domino Tremiti Islands FG 8/10 Very Good! (224 reviews) Friendly staff, great location. Katia at Reception was amazing Reviewed on Aug 2, 2025 [Get rates](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=2942214&PinnedHotelID=2942214&HadPinnedHotel=true®ionId=6125738) [](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=2942214&PinnedHotelID=2942214&HadPinnedHotel=true®ionId=6125738) ![L'ISOLA DEI SAPORI BOUTIQUE HOTEL ](https://images.trvl-media.com/lodging/102000000/101960000/101956900/101956860/413dbf47_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### L'ISOLA DEI SAPORI BOUTIQUE HOTEL STRADA PROVINCIALE 41 KM 34,00 Cagnano Varano FG $97 nightly $106 total Feb 9 - Feb 10 Total with taxes and fees 9.4/10 Exceptional! (19 reviews) For an off season stay (middle of winter in a beach resort) the staff went out of their way to make us welcome. Looking at the summer amenities it would be a great place for a beach holiday. Reviewed on Jan 23, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F9%2F2026&endDate=2%2F10%2F2026&selected=101956860&PinnedHotelID=101956860&HadPinnedHotel=true®ionId=6125738) [See all 24 properties in San Domino](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F9%2F2026&endDate=2%2F10%2F2026®ionId=6125738) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best San Domino Vacation Packages ## San Domino Essential Information | Language | Italian | | --------------- | --------------------------- | | Currency | Euros | | Local Welcome | Ciao | | Local Goodbye | Ciao | | Closest Airport | Abruzzo Intl. Airport (PSR) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app